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John D Shaughnessy Selected Research

heparitinsulfate lyase

9/2007The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
5/2007Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.

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John D Shaughnessy Research Topics

Disease

46Multiple Myeloma
11/2015 - 08/2002
27Neoplasms (Cancer)
01/2021 - 01/2002
10Chromosome Aberrations (Chromosome Abnormalities)
03/2011 - 08/2002
7Bone Diseases (Bone Disease)
09/2014 - 01/2002
4Neoplasm Metastasis (Metastasis)
01/2008 - 02/2007
3B-Cell Lymphoma (Lymphoma, B Cell)
01/2021 - 08/2007
3Paraproteinemias (Monoclonal Gammopathy)
01/2019 - 09/2006
2Disease Progression
10/2008 - 09/2006
2Plasmacytoma
08/2007 - 02/2007
2Breast Neoplasms (Breast Cancer)
05/2007 - 01/2007
1Castleman Disease (Castleman's Disease)
01/2013
1Osteolysis
09/2012
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
09/2012
1Squamous Cell Carcinoma of Head and Neck
12/2011
1Prostatic Neoplasms (Prostate Cancer)
01/2011
1Bone Resorption
06/2009
1Osteoporosis
01/2009
1Smoldering Multiple Myeloma
10/2008

Drug/Important Bio-Agent (IBA)

11Thalidomide (Thalomid)FDA Link
11/2012 - 02/2007
8Bortezomib (Velcade)FDA Link
08/2010 - 04/2007
5Proteins (Proteins, Gene)FDA Link
01/2021 - 10/2004
5Messenger RNA (mRNA)IBA
04/2010 - 10/2004
3CytokinesIBA
01/2019 - 01/2008
3Dexamethasone (Maxidex)FDA LinkGeneric
08/2010 - 01/2008
3L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
09/2009 - 10/2006
2NF-kappa B (NF-kB)IBA
07/2013 - 08/2007
2Proteasome Endopeptidase Complex (Proteasome)IBA
07/2013 - 04/2009
2Proteasome InhibitorsIBA
07/2012 - 02/2008
2Membrane Glycoproteins (Membrane Glycoprotein)IBA
01/2012 - 05/2008
2Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
12/2011 - 07/2003
2Biomarkers (Surrogate Marker)IBA
01/2011 - 02/2007
2beta CateninIBA
03/2010 - 04/2009
2C-Reactive ProteinIBA
09/2009 - 10/2006
2elotuzumabIBA
09/2009 - 05/2008
2Pharmaceutical PreparationsIBA
10/2008 - 01/2002
2Lenalidomide (CC 5013)FDA Link
08/2008 - 05/2007
2Heparitin Sulfate (Heparan Sulfate)IBA
09/2007 - 05/2007
2EnzymesIBA
09/2007 - 05/2007
2heparanaseIBA
09/2007 - 05/2007
2Syndecan-1 (Syndecan 1)IBA
09/2007 - 05/2007
2heparitinsulfate lyaseIBA
09/2007 - 05/2007
2AntigensIBA
09/2007 - 04/2007
2OligonucleotidesIBA
10/2004 - 12/2003
1Growth Factor ReceptorsIBA
01/2019
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
11/2015
1Transcription Factors (Transcription Factor)IBA
11/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2013
1Interleukin-6 (Interleukin 6)IBA
01/2013
1Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
01/2013
1Interleukin-2 (IL2)IBA
09/2012
1Interleukin Receptor Common gamma SubunitIBA
09/2012
1Indicators and Reagents (Reagents)IBA
01/2012
1PaxillinIBA
12/2011
1Ribosomal Proteins (Ribosomal Protein)IBA
12/2011
1Enzyme Precursors (Zymogens)IBA
01/2011
1Prostate-Specific Antigen (Semenogelase)IBA
01/2011
1Parathyroid Hormone (Parathormone)IBA
12/2010
1Diphosphonates (Bisphosphonates)IBA
12/2010
1Bone Density Conservation AgentsIBA
12/2010
1MicroRNAs (MicroRNA)IBA
04/2010
1Cyclin D1IBA
02/2010
1Cyclin D3IBA
02/2010
1Early Growth Response Protein 1IBA
01/2010
1Monoclonal AntibodiesIBA
09/2009
1Peptide Hydrolases (Proteases)FDA Link
06/2009
1talabostatIBA
06/2009
1Propidium (Propidium Iodide)IBA
04/2009
1Aurora KinasesIBA
04/2009
1IodineIBA
04/2009
1Immunoglobulin IsotypesIBA
04/2009
1Estrogens (Estrogen)FDA Link
01/2009
1GlucocorticoidsIBA
01/2009
1Melphalan (Alkeran)FDA LinkGeneric
12/2008
1LigandsIBA
12/2008
1fludarabineIBA
12/2008
1Biological ProductsIBA
11/2008
1Immunoglobulins (Immunoglobulin)IBA
07/2008
1Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA
07/2008
1OsteoprotegerinIBA
07/2008
19-(dimethylaminoethoxy)ellipticineIBA
03/2008
1Antineoplastic Agents (Antineoplastics)IBA
03/2008
1ellipticineIBA
03/2008
1HLA Antigens (Human Leukocyte Antigens)IBA
02/2008
1Small Interfering RNA (siRNA)IBA
01/2008
1Tyrosine (L-Tyrosine)FDA Link
01/2008
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2008
1Sulfates (Sulfates, Inorganic)IBA
09/2007
1Imatinib Mesylate (Gleevec)FDA Link
08/2007
1Phosphotransferases (Kinase)IBA
08/2007
1pristane (pristan)IBA
08/2007
1CreatinineIBA
07/2007
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
05/2007
1Glycogen Synthase Kinase 3 betaIBA
05/2007

Therapy/Procedure

30Therapeutics
09/2014 - 01/2002
3Stem Cell Transplantation
09/2006 - 01/2002
2Immunotherapy
09/2012 - 09/2007
2Drug Therapy (Chemotherapy)
10/2011 - 01/2011
2Transplantation
08/2007 - 01/2002
1Salvage Therapy
10/2008
1Autologous Transplantation
08/2007